Review: In Pursuit of Memory – Joseph Jebelli

024 - In Pursuit of Memory

024 - In Pursuit of Memory

Rating – 4*

Happy Friday folks, and today I am treating you to another Wellcome Prize longlisted book review. This time it is In Pursuit of Memory – the biography of a disease which affects far too many of us in one way or another – Alzheimer’s.

This book is both a personal account, the authors own motivations and reasoning to the research in to this subject and also a definitive overview of where research is now and what life looks like with Alzheimer’s disease. His own motivations into researching this subject is his beloved grandfather who was showing the early symptoms when the author was just 12. It is this what motivated him to become who he is today, one of the most respected Alzheimer’s disease experts

For me this contained just the right amount of history, science, and personal opinion. There was a good balance of all three and I never found myself bored. I also found that while there was quite a bit of science in here it wasn’t overwhelming so someone who just has a personal interest in the topic would be able to follow this and learn from it quite easily. The personal stories, not just of the authors family but of other families he has spoken to in the making of this book, touched me. Everyone has a very different story with this disease, and it makes me very sad that we still don’t know very much about it.

What I did find fascinating was the more population based genetics behind Alzheimer’s – for example people in Iceland don’t seem to develop it due to a mutation in their DNA. The close knit community which descends from a very small gene pool have pretty much eradicated the heritable genetic factor which is known to cause the disease. Whereas there’s communities in India and Columbia where the inverse is true, the small gene pool has resulted in nearly everyone in the family or the community as a whole having the mutation which increases likelihood of succumbing to Alzheimer’s. I find things like that absolutely incredible!

I think it’s the balance of the emotional and personal side and the scientific side which makes this book so special. I think had I read it a little bit after With the End in Mind I may have rated it 5* – because it is a fantastic book, but that was still weighing heavily on my thoughts and probably impacted how I felt about this book.

Definitely worth a read if you have any interest in Alzheimer’s, memory, or general science non-fiction!

 

Review: With the End in Mind – Kathryn Mannix

023 - With the End in Mind

023 - With the End in Mind

Rating – 5*

Hands down this book is one of the best I have read this year – possibly ever. It was by no means an easy read, but it was incredible and trying to put in to words the profound affect this book has already had on me is difficult.

Dr Kathryn Mannix is a palliative care consultant – she has seen a lot of people dying and, in this book, is trying to relieve the stigma that modern society has around death and the process of dying. It is something as natural as birth and waits for us all but it’s something we don’t really talk about, least of all with those people in our lives who it really matters to talk about it with!

She explores the pattern of dying – what most people experience at any rate. But rather than doing it in medical jargon she tells stories – the patients who lives (and deaths) touched her in some way. The care she and her teams over the years have for patients in their final minutes is the care we all wish we could experience, but fear among loved ones means that often that gentle, understanding death doesn’t happen. She takes time to explain to loved ones the patterns, what they can expect and honestly, it is the frank and honest conversation that so many more people should have when keeping vigils at someones bedside. I know I’d have benefited from this woman – or even this book – 3 and a half years ago when I said goodbye to my grandmother.

This book had me sobbing. Fat, ugly tears. Each chapter is someones story, their life, their death, and what she as a clinician learnt from them. She does justice to each one of the lives she tells in this book, she handles them all with grace and dignity. Equally, parts of this book had me laughing. That is something I was definitely not expecting in a book about death! At some points I was somehow doing both simultaneously.

Mannix does also tell some personal stories – how sitting on the other side of the fence (so to speak) with her own grandmother was something which only made her a better doctor, it was something she learnt from. And also how she had the conversation with her son when their cat had been injured and wasn’t going to survive. I’m not going to lie, I cried when the cat died too.

I cannot praise this book enough. So far it’s a head and shoulders above the rest on the long list and, honestly, if this doesn’t get short listed I may well kick off! As I said at the start, it is by no means an easy read but I think it’s a necessary read for so many people. Death shouldn’t have a stigma attached to it and this book is absolutely hammering this point home.

I put on twitter that I’d like this to be on prescription – and I really thing it ought to be. Maybe not prescription, but it should definitely be handed out to people facing an imminent death of a loved one.

My only criticism is that in parts it was repetitive, but honestly every time I felt that it affected me just as much. It was an absolutely beautiful book, and so far it’s my front runner.

I would also like to say that I listened to this as an audiobook in parts, I found that a really good way to take it in. Elizabeth Carling was a fantastic narrator for this, her tone was just right and it really had a positive impact on my overall feelings about this book. If you’re a little unsure about it, definitely give the audiobook a go because it was marvellous.

Review: The White Book – Han Kang

022 - The White Book

022 - The White Book

Rating – 3*

In the last week I’ve somehow managed to get through 4 of the Wellcome Book Prize long listed books. This was the first of them, and actually one of my more anticipated books on the longlist as it’s by an author who I’ve heard of! This will be a relatively short review as the book itself was only 130 pages or so long!

The White Book by Han Kang is a rather short and sparse book, and one that having read I’m confused as to why it appears on the longlist. It’s a ‘concept’ book in my eyes, the writing is short and punchy, there isn’t a whole lot of depth to it, it’s vague and focuses very heavily on imagery.

The story behind this book is the loss her parents experienced when her oldest sister was born two months premature in a harsh winter and there was no way that she’d survive. It is heavily biographical, and I think the experimental nature of the writing comes from it being a cathartic piece that was meant for her more than anyone else. There is a lot of blank space – white space if you will – and some of it reads like poetry, some of it like prose. Some of it is vague and out there other parts are clear as a bell. There’s a disparity to this book and, for some reason, it just didn’t settle with me.

It was a powerful book in parts, the parts directly dealing with loss, grief, premature birth and the things which this book was nominated for the Wellcome Prize for were great but, as far as the prose goes I felt it was a bit too far out there for me! I’m not going to say it was a bad book, because a lot of it was great, some of the imagery was great but reading it in line with a book prize about biosciences and medicine, and also comparing it to her previous books translated in to English it did fall short of the mark for me unfortunately.

Review: The Vaccine Race – Meredith Wadman

019 - The Vaccine Race

019 - The Vaccine Race

Rating – 3*

Vaccines are an incredibly interesting topic – and interestingly enough one that I only know the bare bones about. This book was one on the Wellcome Prize longlist that I probably would have eventually picked up because the topic is one that I would gravitate towards in the non-fiction section of a bookshop.

The Vaccine Race spans the history of the vaccination – the science, the people behind them, politics, competition and ethics. At the core, it’s a very rounded and thought out book but I felt that it was too little of everything and it was trying too hard to be a more intimate and personal book and it sort of let some of the science fall to the side in places, which was a little disappointing.

I will say I enjoyed the science in this book, and I did like that as I was reading it felt like a race against time to get the vaccinations figured out before any more damage can be caused. I do enjoy reading about scientific and medical ethics, and I’m glad it was covered in pretty much every part of this book. Wadman in no way approves of the methods by which Hayflick tested his creations, but she explains that by the culture of the period he was working in that it was acceptable. Thankfully, science and ethics have moved on from going straight in to human trials on non-consenting participants!

I’ve seen this book compared to The Immortal Life of Henrietta Lacks and while I feel that it was written in the same tone in parts, what made that book incredible made this one only mediocre. Which makes me sad because I really wanted to love this book.

Unfortunately for me this missed the mark. I found the first 100 pages or so really interesting, the first chapter I was absolutely hooked on it, but from there it became a really hard read. It became a chore. Where I read 11 books before I started this one, it took the entirety of the second half of February for me to finish this. The start really lured me in to a sense that this was going to be an amazing book, and yeah, it just didn’t continue in the same way.

Review: I Am, I Am, I Am – Maggie O’Farrell

017 - I Am I Am I Am

017 - I Am, I Am, I Am

Rating – 3*

This book has been receiving incredible reviews, and I was very excited to finally get to it because it sounded interesting. As with a lot of the Wellcome Prize longlist, they’re not books I would ordinarily pick up and that was certainly the case with this.

Firstly, I will say, the cover is gorgeous, I love it (and if anyone is interested, the header for this post is an electron microscope image of heart cells, to pay homage to the beauty of it).

The premise of the book is the author telling stories from her life from the near-death experiences she’s had. It is a really interesting concept, and one I was quite morbidly fascinated by. Although it’s billed as quite a sensational book, with the byline of “seventeen brushes with death” it’s a lot more reflective and intimate than it may be sold as. Also, the final chapter is about her daughter (which actually, for me, was the most poignant chapter) and a couple of the ‘brushes with death’ are tenuous at best. Not to make light of her life, but not all of it felt entirely relevant to the premise.

I’ve never read O’Farrell’s fiction, and while the writing in this book was beautiful on the whole I’m not entirely sure her writing is for me. Some of the meandering thoughts were just too much for me, and sometimes her writing I found a bit grating. That isn’t to say it wasn’t good, it was, I just felt that maybe an editor could have taken a bit more time and care to make it flow a lot better. Another thing about this book which was a bit baffling is the timeline. It’s all over the place. Maybe it was done to keep you reading, I don’t know, but generally speaking I like a memoir to move chronologically and this was backing and forthing.

There are so many positive reviews for this book, people raving about it, saying how much they connected to it. I just didn’t. I didn’t connect, I didn’t like the meandering prose, I didn’t enjoy the timeline being all over the place. And, writing this review a week on, it hasn’t been a book that stuck with me. In a way I understand how people might connect with this book, but for me it just wasn’t that five star read everyone has been raving about.

Review: Mayhem – Sigrid Rausing

016 - Mayhem

016 - Mayhem

Rating – 2*

Another day, another review for the Wellcome Prize longlist. Today I’m talking about Mayhem – which is a memoir about addiction and the impact it has on a family. While it was interesting, and intimate in parts, I didn’t find myself blown away by it, in fact I don’t feel there is much to say about it.

Rausing is the granddaughter of the man who found Tetra Pak, and her brother Hans is who this book is ultimately about. In 2012, after being arrested for possession of class A drugs, his London home was searched by the police where Eva – his then wife – was found dead. She had been dead for 2 months when the police found her. At the crux of it all was drugs – and this book (told from his sister Sigrid’s perspective) is essentially his side of the story, how he came to be addicted, how he and Eva tried to conquer their demons and ultimately the disease which is addiction.

I found the sections which focus on the science of addiction, the whole is it nature or is it nurture debate, really interesting and compelling. I can see why, based on these sections alone, it was longlisted but for me it lacked something. It was a personal story, but I felt constantly detached from the narrative. While I can tell that this is an emotional book for the author to write, it can’t have been easy reliving what was an absolutely awful period of history for her family, it came across to me as a bit narcissistic.

For me, personally, I don’t understand why this book is on the Wellcome longlist. It’s okay, it’s a memoir, but it doesn’t have that impact that things like When Breath Becomes Air or even The Immortal Life of Henrietta Lacks did – and they’re comparable having both been shortlisted (and winning) the prize in the past. On the whole, a bit of a miss for me.

Review: The Butchering Art – Dr Lindsey Fitzharris

014 - The Butchering Art

014 - The Butchering Art

Rating – 4*

This is the first of many reviews for books on the Wellcome Prize 2018 Longlist. It definitely isn’t for the squeamish reader as it is the very gruesome biography of Joseph Lister – the father of modern antiseptics.

Often the Victorian era is idealised, romanticised, the reality is that you were going to die, very young, of something that was most certainly preventable. It says something when surgery in your dining room was less likely to kill you than surgery in a hospital. In a hospital surgeons would wear the same clothes between patients, use instruments covered in blood, guts and gore from the previous surgery, they didn’t even think twice about using instruments they’d just used on an autopsy on a (still) living patient. Cross contamination and sepsis were significant causes of death – and leeches couldn’t fix everything. Surgery in the 1800s was a matter of speed – there wasn’t anaesthetic and things had to be done quickly to avoid excess blood loss and trauma, and of those who survived the majority then died because of post-operative infection.

Lister, as a young surgeon, saw a problem and decided he wanted to do something to try and fix it. His antiseptic theories were groundbreaking, and most certainly unpopular. He spent is career building the argument, and in the end even with evidence people were still against him. The backlash he faced seems ridiculous now – in a society which is so germ averse, with antibacterial hand wash on every wall in a hospital and most of us carrying it in a bag! But just 150 years ago it was reality, and he saved so many lives because he persevered.

Medical history isn’t something I can honestly say I’ve read about, obviously I know it’s there, and I knew of Joseph Lister and his importance but actually picking a book up about it is not something I would have done without the Wellcome Prize longlist. Ultimately I’m really glad I read this – Joseph Lister was an incredible man on a mission, and has changed all of our lives because of it.

Dr Lindsey Fitzharris is a compelling story teller, that much is sure. This could have been a very, very dry book but it wasn’t and I think it’s because it was quite a personable account – rather than reading like a textbook it just reads like a biography but at the same time I feel I learnt a lot from it. I’ll definitely be recommending this to my stronger-stomached friends!

Wellcome Book Prize 2018 || Longlist Discussion

WBP Longlist

Happy Saturday my lovely readers, and welcome to a bonus post this week in which I am going to discuss my most anticipated bookish event of 2018 so far – the announcement of the Wellcome Book Prize longlist.

For those of you unfamiliar with the Wellcome Prize , to summarise it is an an annual prize and eligible books are those which have central themes of medicine, health, illness, or biosciences. Because of this broad criteria the lists of books nominated are from a number of genres – both fiction and non-fiction, but can span across any sub-genres of those. And I love it.

Last year I managed to read the shortlist, this year I want to read the entirety of the longlist. As I write this I have already read 2 of the books – one is Stay With Me by Ayọ̀bámi Adébáyọ̀ which I read last Summer, and the second is The Butchering Art as when I was reading through the descriptions of each book that one was one I wanted to read asap. So I did.

So, without further ado, the books:-

 

Wellcome Longlist

image courtesy of WellcomeBookPrize.org

 

As you can see from the picture there is an enormous amount of variety – and something I am very happy about is the amount of books that I hadn’t even heard of on this list. I can say that there are 3 books here that I knew existed and the rest have me very, very excited (so excited that I have bought a huge number of them already!)

I’d be interested to hear if any of you reading this have seen any of these books (the ones I am familiar with are Stay With Me, The White Book and I Am, I Am, I Am – the rest I know nothing about!) and if you have read any too. If you have, are there any you think I ought to get to sooner rather than later?

The shortlist is announced on March 20th – thankfully a Tuesday (I don’t work Tuesdays) – and I’m hoping to have got through the bulk of this longlist by then. Needless to say I have a few very, very exciting reading weeks ahead of me and I for one cannot wait!

As I said above, I’d love to hear your thoughts on the Wellcome Prize. For me it’s one of the most varied, vibrant literary prizes out there because it focuses across such a wide breadth of genres. I also think it’s a very accessible prize – those of you not as confident or comfortable reading science based non fiction can definitely still enjoy this prize as there’s a decent amount of variety and, for me at least, even the non-fiction is easy to read and get your teeth in to.

So, in the next few weeks you can expect to see all 12 (well, 11 because I don’t think I’ll be re-reading Stay With Me) of these books reviewed. Hopefully before March 20th! Wish me luck.

 

Review: The Immortal Life of Henrietta Lacks – Rebecca Skloot

046 - The Immortal Life of Henrietta Lacks

Rating – 5*

Putting my feelings for this book in to coherent sentences is going to be hard. This is a book I’ve been aware of long before I started my degree, and I really wish I had read it prior to university because it would have given me a different aproach to my day to day lab work. I knew her name, which is more than many scientists did, but when dealing with cell cultures it’s sometimes difficult to remember that every cell came from somewhere, and in many cases came from someone. More importantly, the immortal cell line – HeLa – which came from her tumor has changed the lives of everyone alive today. Yet, she was unknown until 20 years after the biopsy was taken, and she doesn’t get thanks for that.

This book was so much more than a book about cells – I’ve read many of books about cells and this wasn’t comparable to any of them. This is the biography of a woman science – the world – needs to remember the name of. Henrietta Lacks. Henrietta Lacks was a young mother of 5 when she was diagnosed with cervical cancer, and unknown to her or her family the doctor took two biopsies that day. One would diagnose her with cancer, the other would go on to be the most prolific cell line in history. HeLa cells have gone on to change the world – they were instrumental in the development of medical treatments such as the polio vaccine, they’ve been in to space, they’ve changed the face of science and medicine to what we now know it. But this is a book about the woman behind that immortal cell line; the mother, sister, wife, cousin, and friend. It’s a book full of compassion and it made me cry because I know just how instrumental this woman has been in my life.

The story in these pages is not an easy read. It covers race, religion, discrimination of many kinds, the American medical system (which to this day horrifies me), medical ethics, rights to our bodies and tissues – what it covers seems to be endless. There is also a brief touch on mental health in the book, due to one of Henrietta’s children – Elsie – suffering from epilepsy and being institutionalised at a very young age. While we never know the exact details of how the poor girl was treated while in the ‘care’ home, the general opinion on what was likely to have occurred sent a shiver down my spine. But for me, the thing which gave me most hope, was that education is power. Deborah, one of Henrietta’s children, armed with a dictionary and google, was determined to learn as much about her mother and what her cells have done for the world as possible.

Rebecca Skloot is a fantastic journalist who became fascinated by the story of the woman behind the cells when she was in college. She knew from a reasonably early point in her career that this was the book she wanted to write because the more she understood, the more she wanted to know about Henrietta. She handles this book with extreme grace and compassion, with very much overdue respect and gratitude to the family in every page of this book.

Honestly, this book is one that will stay with me for a lifetime. It’s not your typical, stodgy non-fiction as it’s more about the woman, not the science. It’s approachable and informative, and a very much deserved winner of the Wellcome Prize in 2010. I cannot recommend it highly enough.

I leave you on this note:- HeLa cells, which were taken from the tumour on Henrietta Lacks’ cervix – were found to contain human papillomavirus 18 (HPV-18). HPV-18 is one of the strains of HPV which can cause cervical cancer, and in 2006 the cell line from Henrietta was used to develop a vaccine which is now given to all female school children in the UK (and many countries worldwide) which has, on estimate, cut cervical cancer cases by two thirds in 10 years. It’s by no means a cure, but it reduces the risk. That, for me, is something I feel both Henrietta (and her family) should be very proud of.

Discussion: Wellcome Book Prize 2017

I had intended for this to be a post before the winner was announced – however, that plan got put on the backburner and here I am now, 45 minutes after the winner was announced, a little in shock. It’s the most wonderful kind of shock because I am so, so happy with which book has been named the winner.

To warn you, this is a 500 word ramble.

In case you haven’t seen who won – I’m about to spoil it for you. It was Mend the Living by Maylis de Kerangal. This has made Wellcome Prize history as it’s the first book to have been translated and won, which is incredible – and honestly a testament to the translation skill. In a prize shortlist which was so diverse, fiction and non fiction, men and women, the possibility of a posthumous award, the outcome of a translated book winning – honestly it’s boggling how wonderfully diverse the shortlist was and I really, really love that this book won.

Mend the Living didn’t shout like some books do, it was more quiet in what it was putting across. It’s one that the more I’ve thought about since I finished it 2 weeks ago, the more I’ve loved it – to the point that I actually changed my rating on goodreads and bumped this up to a 5* book. It was quiet in both the way it was written, and also the media surrounding it – a lot of focus was on When Breath Becomes Air and The Tidal Zone. The hard science in The Gene and I Contain Multitudes was overwhelming and impressive, and I enjoyed both those books.

For me, the two it came down to were How to Survive a Plague and Mend the Living – out of the two the better book won in my opinion. They were both a lot less publicised, somewhat pushed to the back of the tables in my local bookshops, they were definitely not talked about enough. I actually had a conversation with a few of the booksellers in my local Waterstones, and told them that out of the entire shortlist Mend the Living was the one I would say ‘read’ – and a couple of them did.

I’m quite sad I didn’t put a prediction post up – because I would so love to have been right before the event (it’s all very well and good saying I TOLD YOU SO, but when there’s no evidence to back it up it’s not nearly as impressive!)

Seriously folks, read this book. It’s incredible and it really won’t disappoint. It’s a very, very worthy winner and I will be thrusting it in to several people’s hands in the near future. I hope that several more of her books are translated in to English because I would so, so love to see what else this woman can write.

If you can’t tell, I’m very happy.