Happy Friday folks, and today I am treating you to another Wellcome Prize longlisted book review. This time it is In Pursuit of Memory – the biography of a disease which affects far too many of us in one way or another – Alzheimer’s.
This book is both a personal account, the authors own motivations and reasoning to the research in to this subject and also a definitive overview of where research is now and what life looks like with Alzheimer’s disease. His own motivations into researching this subject is his beloved grandfather who was showing the early symptoms when the author was just 12. It is this what motivated him to become who he is today, one of the most respected Alzheimer’s disease experts
For me this contained just the right amount of history, science, and personal opinion. There was a good balance of all three and I never found myself bored. I also found that while there was quite a bit of science in here it wasn’t overwhelming so someone who just has a personal interest in the topic would be able to follow this and learn from it quite easily. The personal stories, not just of the authors family but of other families he has spoken to in the making of this book, touched me. Everyone has a very different story with this disease, and it makes me very sad that we still don’t know very much about it.
What I did find fascinating was the more population based genetics behind Alzheimer’s – for example people in Iceland don’t seem to develop it due to a mutation in their DNA. The close knit community which descends from a very small gene pool have pretty much eradicated the heritable genetic factor which is known to cause the disease. Whereas there’s communities in India and Columbia where the inverse is true, the small gene pool has resulted in nearly everyone in the family or the community as a whole having the mutation which increases likelihood of succumbing to Alzheimer’s. I find things like that absolutely incredible!
I think it’s the balance of the emotional and personal side and the scientific side which makes this book so special. I think had I read it a little bit after With the End in Mind I may have rated it 5* – because it is a fantastic book, but that was still weighing heavily on my thoughts and probably impacted how I felt about this book.
Definitely worth a read if you have any interest in Alzheimer’s, memory, or general science non-fiction!